| 滋补肾阴方药对D-半乳糖拟衰小鼠自由基代谢及免疫功能的影响 |
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| 引用本文： | 王燕.滋补肾阴方药对D-半乳糖拟衰小鼠自由基代谢及免疫功能的影响[J].时珍国医国药,2007,18(11):2770-2771. |
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| 作者姓名： | 王燕 |
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| 作者单位： | 广东医学院,广东,湛江,524023 |
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| 摘 要： | 目的研究滋补肾阴方药对D-半乳糖(D-gal)所致衰老小鼠自由基代谢及免疫功能的影响。方法采用D-gal复制衰老小鼠模型。测定衰老小鼠血清中丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性,胸腺指数和脾指数,脾脏T淋巴细胞增殖活性及血清中白介素-2(IL-2)水平,并观察滋补肾阴方药对上述指标的影响。结果滋补肾阴方药能明显提高血清中SOD活性,降低血清中MDA含量,并提高胸腺指数、脾指数,脾脏T淋巴细胞增殖活性和血清中IL-2水平。结论抑制脂质过氧化反应,提高抗氧化酶活性,改善免疫功能可能是滋补肾阴方药延缓衰老的作用机制之一。
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| 关 键 词： | 中医药疗法 衰老模型 自由基 免疫 |
| 文章编号： | 1008-0805（2007）11-2770-02 |
| 收稿时间： | 2007-02-05 |
| 修稿时间： | 2007-06-20 |
The Effect of Invigorating Kidney-YIN Recipe on Free Radical Metabolism and Immune Function of Aging Mice Induced by D-gal |
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| WANG Yan.The Effect of Invigorating Kidney-YIN Recipe on Free Radical Metabolism and Immune Function of Aging Mice Induced by D-gal[J].Lishizhen Medicine and Materia Medica Research,2007,18(11):2770-2771. |
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| Authors: | WANG Yan |
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| Institution: | Department of Microbiology and Immunology, Guangdong Medical College, Zhanjiang, Guangdong 524023, China |
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| Abstract: | Objective To explore the effect of invigorating kidney-YIN recipe on the free radical metabolism and immune function of aging mice induced by D-gal.Methods Malondialdehyde(MDA) content and superoxide dismutase(SOD) activity in serum,thymus indexes, spleen indexes, activity of T lymphocyte and the level of IL-2 were determined in aging mice induced by D-gal.The effect of invigorating kidney-YIN recipe on the above indexes was observed.Results The invigorating kidney-YIN recipe could significantly increase SOD activity in serum; decrease MDA content in serum, enhance thymus indexes, spleen indexes, activity of T lymphocyte and serum IL-2 content.Conclusion To inhibit lipid peroxidation,increase activity of antioxidase and improve immune function might be one of the mechanisms of invigorating kidney-YIN recipe against aging. |
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| Keywords: | Therapeutics of traditional medicine Aging model Free radicals Immune |
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