| 急性呼吸窘迫综合征患者血清和支气管肺泡灌洗液中白介素-1β的变化 |
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| 引用本文： | 罗显荣,伍伟玲,王琳,叶小群,张丹. 急性呼吸窘迫综合征患者血清和支气管肺泡灌洗液中白介素-1β的变化[J]. 中国危重病急救医学, 2003, 15(6): 365-366 |
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| 作者姓名： | 罗显荣 伍伟玲 王琳 叶小群 张丹 |
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| 作者单位： | 解放军第四五八医院呼吸科,广东,广州,510602 |
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| 基金项目： | 广东省重点科技基金资助项目 ( 2 0 0 0 9813 6) |
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| 摘 要： | 目的 :探讨白细胞介素 1β(IL 1β)在急性呼吸窘迫综合征 (ARDS)发病中的作用。方法 :用酶联免疫吸附试验检测了 13例 ARDS患者和 9例健康者支气管肺泡灌洗液 (BAL F)和血清中 IL 1β含量。结果 :ARDS患者 BAL F及血清中 IL 1β含量〔分别为 (14 4 .6 7± 80 .79) ng/ L 和 (4 5 .71± 7.0 9) ng/ L〕明显高于对照组〔分别为 (2 0 .39± 1.87) ng/ L 和 (35 .0 6± 5 .4 6 ) ng/ L,P=0 .0 0 0和 P=0 .0 0 1〕,且 ARDS患者 BAL F中IL 1β含量也明显高于血清 (P=0 .0 0 0 )。结论 :IL 1β参与了 ARDS的发病过程 ,早期测定 ARDS患者肺内细胞因子可能比血液或血浆中更有价值。
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| 关 键 词： | 白细胞介素—lβ 急性呼吸窘迫综合征 支气管肺泡灌洗液 血清 |
| 文章编号： | 1003-0603(2003)06-0365-02 |
| 修稿时间： | 2002-06-21 |
Changes in interleukin-1β in serum and bronchoalveolar lavage fluid in the patient with acute respiratory distress syndrome |
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| LUO Xianrong,WU Weiling,WANG Lin,YE Xiaoqun,ZHANG Dan. Changes in interleukin-1β in serum and bronchoalveolar lavage fluid in the patient with acute respiratory distress syndrome[J]. Chinese critical care medicine, 2003, 15(6): 365-366 |
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| Authors: | LUO Xianrong WU Weiling WANG Lin YE Xiaoqun ZHANG Dan |
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| Affiliation: | Department of Respiratory Disease, Airforce Hospital of People's Liberation Army, Guangzhou, 510602 Guangdong, China. |
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| Abstract: | OBJECTIVE: To study the role of interleukin-1beta (IL-1beta) in the pathogenesis of acute respiratory distress syndrome (ARDS). METHODS: The bronchoalveolar lavage fluid (BALF) and serum in 13 patients with ARDS and 9 healthy controls were collected. The contents of IL-1beta were measured by enzyme-linked immunoadsorbent assay(ELISA). RESULTS: The levels of IL-1beta in BALF [(144.67+/-80.79)ng/L] and serum [(45.71+/-7.09)ng/L] in patients with ARDS were significantly higher than those in the control groups [(20.39+/-1.87)ng/L, P=0.000; (35.06+/-5.46)ng/L, P=0.001, respectively], and the levels of IL-1beta in BALF were also significantly higher than those of the serum in the patients with ARDS (P=0.000). CONCLUSION: The results indicate that IL-1beta is involved in the pathogenesis of ARDS. Early determination of IL-1beta level in BALF may be more valuable in the evaluation of disease process of ARDS. |
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