S—100蛋白,癌胚抗原和波形蛋白在骨和软骨肿瘤及瘤样病变中的分布

本文对60例骨和软骨肿瘤及瘤样病变进行了S-100蛋白(S-100),癌胚抗原(CEA)和波形蛋白(Vim)的检测。结果表明内生软骨瘤、骨软骨瘤、软骨母细胞瘤,软骨肉瘤等中的软骨细胞、软骨母细胞和骨肉瘤中软骨分化的区域显示S-100阳性反应,提示S-100可以做为软骨细胞和软骨细胞分化的一个标志。分化好的软骨细胞S-100反应强,分化差的反应弱甚至阴性。 软骨母细胞瘤有时需与出现多核巨细胞的骨疾患相鉴别,此时检测S-100有较大价值。最后对软骨原性肿瘤显示S-100阳性反应的机理进行了讨论。

S-100 ,CEA AND VIM IN TUMORS AND TUMOR-LIKE LESIONS OFBONE AND CARTILAGE

Using the PAP-and ABC immunohistochemical methods, S-100, CEA and VIM were found in chondrocytes of enchondroma, osteochondroma.chondrobkstoma, chondrosarcoma and mesenchymal chondrosarcoma and chondrocyts differentiated area of osteosarcoma S-100 positity correlated with the, degree of differentiation of chondrocytes.The result suggests that S-100 may be a marker of chondrocytic origin and degree offferentiation of chondrocyte.Well differentiated chondrocytes showed strong reaction of S -100, while the poorly differentiated omes showed weak or no reaction of S -100.