鼻咽癌放疗后中耳积液的原因浅析

目的:探讨鼻咽癌放疗后中耳积液的相关因素。方法:对34例长期存在中耳积液的放疗后鼻咽癌患者,采用χ2检验和优势比方法,分析患者的鼻咽原发灶T分期、性别、鼻咽原发灶侵及鼻咽侧壁或咽旁间隙等因素与放疗后产生中耳积液的关系。结果:患者性别、鼻咽原发灶T分期对放疗后中耳积液的发生无影响(P>0.05);而鼻咽肿瘤侵及鼻咽侧壁、咽旁间隙与放疗后中耳积液长期存在关系密切(P﹤0.05、P<0.01)。结论:放疗前有肿瘤侵犯鼻咽侧壁而导致放疗后中耳积液长期存在的风险是放疗前无肿瘤侵犯鼻咽侧壁的4.33倍,肿瘤侵犯咽旁间隙而出现放疗后中耳积液长期存在的风险是放疗前无肿瘤侵犯咽旁间隙的3倍,而放疗后中耳积液的发生与性别、鼻咽原发灶T分期无关。

Middle-ear effusion after radiotherapy in patients with nasopharyngeal carcinoma

Objective To discuss the possible reasons of middle - ear effusion after radiotherapy in patients with nasopharyngeal carci- noma. Method 34 cases who suffered from nasopharyngeal carcinoma were reviewed with chi - square test and odds ratio. Results Sex and primary tumor type were not related to middle - ear effusion （ P 〉 0. 05 ）. But tumor invasion to the lateral wall of nasopharyngeal and para- pharyngeal space had close relation to middle - ear effusion（ P 〈 0. 05 ,P 〈 0.01 ）. Conclusion The risk of middle - ear effusion after ra- diotherapy in patients with nasopharyngeal carcinoma when tumor invasion to the lateral wall of nasopharyngeal and parapharyngeal space were 4. 33and 3 times than not.