The in vivo effect of acriflavine on mitochondrial functions in the petite negative yeast Hansenula saturnus |
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| Authors: | A. M. Viola P. Goffrini P. P. Puglisi I. Ferrero |
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| Affiliation: | (1) Institute of Genetics, University of Parma, Borgo Carissimi No. 10, I-43100 Parma, Italy |
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| Abstract: | ![]()
Summary In the petite negative yeast Hansenula saturnus, acriflavine determined a decrease of cell yield and of the total QO2,the disappearance of the cytochromes aa3 and b and the inhibition of in vivo mitochondrial protein synthesis without affecting the cell survival. The restriction enzymes analysis of mitDNA shows that no specific fragmentation occurred after acriflavine treatment. |
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| Keywords: | Mitochondrial DNA Petite negative yeast Hansenula saturnus Acriflavine |
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