18 三体腭裂小鼠颅颌面发育畸形的形态测量学研究

目的 通过对１８三体胚鼠和正常胚鼠的比较形态测量学研究，量化地认识该腭裂模型大体及颅颌面先天性发育不足。方法 采用６０只Ｈａｎ－ＮＭＲＩ母鼠及１１只具有Ｒｂ（２．１８）６Ｒｍａ／Ｒｂ（１．１８）Ｒｍａ染色体结构的雄鼠，从５６９只子代活胚中选择５２对胎鼠作为研究对象，其中每对包括一只正常胚鼠和一只与正常胎鼠体重相近的三体伴发腭裂的胎鼠。借助大体形态测量学手段对５２对样本进行形态学测量研究。结果 腭裂

Morphometrical study on the development of the trisomy-18 with cleft palate and euploid mice

Objective To quantitatively compare the whole body, the lateral maxillofacial profile in Ts18 foetuses with cleft palate (Ts CP) and euploid foetuses in order to answer the question whether this animal model is associated with maldevelopment or hypoplasia of the craniomaxillofacial region Methods Sixty female Han- mice and 11 male mice with the Rb(2 18)6Rma and Rb(1 18) 10Rma chromosomes were used to generate 569 living foetuses Of these, 52 pairs Ts CP and euploid foetuses were selected according to about equal body weight, and used in gross morphometric study Results Ts 18 foetuses had greater body flexion, a significant maxillary and mandibular retrusion , also mandible in Ts CP foetuses were smaller than in euploids without cleft Conclusions This animal model of congenital cleft palate developed hypoplasia of the maxilla and mandible