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Ultrastructure of lentigo maligna in the oral cavity
Authors:Nobuyuki Tanaka   Yutaka Kimijima   Masafumi Mimura   Akira Yamaguchi   Shizuko Ichinose   Gen-iku Kohama  Masaaki Satoh
Affiliation:(1) Department of Oral Surgery, Sapporo Medical University School of Medicine, Minami-1. Nishi-16, Chuo-ku, 060 Sapporo, Japan;(2) The First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan;(3) Central Electron Microscopic Laboratory, Tokyo Medical and Dental University, Tokyo, Japan;(4) Department of Clinical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
Abstract:A rare case of lentigo maligna in the oral cavity was investigated by light and electron microscopy. Cutaneous lentigo malignas often develop to malignant melanomas. However, the electron microscopic examination revealed that even though there were a large number of melanosomes, most of them were late stage and had membrane structure, and positive staining with HMB-45 was not recognized. From our findings, it is difficult to conclude that oral lentigo malignas develop malignant melanomas, and thus further studies are needed.
Keywords:Lentigo maligna  Oral cavity  Late-stage melanosome  HMB-45
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