非小细胞肺癌组织中VEGF-C表达与淋巴转移的关系

目的 探讨非小细胞肺癌（NSCLC）组织中血管内皮生长因子C（VEGF-C）表达情况与肿瘤淋巴转移的关系.方法 采用免疫组织化学方法检测NSCLC肿瘤组织中VEGF-C阳性表达情况和微血管、微淋巴管的密度,分析VEGF-C阳性表达与肿瘤分化情况、淋巴结转移情况、病理类型的关系,比较有、无淋巴结转移和VEGF-C阳性、阴性表达的不同肿瘤组织中微血管和微淋巴管的密度.结果 有淋巴结转移肿瘤组织VEGF-C的阳性表达率高于无淋巴结转移肿瘤组织（x2=15.461,P＜0.05）；不同分化程度和不同病理类型的NSCLC组织中VEGF-C的阳性表达率差异无统计学意义（P＞0.05）.VEGF-C阳性表达的NSCLC组织微淋巴管计数高于VEGF-C阴性NSCLC组织（t=22.080,P＜0.05）；有淋巴结转移NSCLC组织微淋巴管和微血管计数高于无淋巴结转移NSCLC组织（t分别为37.312、20.847,P＜0.05）.结论 VEGF-C可能通过调节微淋巴管生成的数目促进NSCLC的淋巴转移.

Relationship between VEGF-C expression and lymphatic metastasis in non-small cell lung cancer

Objective To investigate the relationship between the expression of vascular endothelial growth factor C （VEGF-C） and the tumor lymphatic metastasis in the non-small cell lung cancer （NSCLC）.Methods The immunohisto- chemist）, was used to detect the positive expression of VEGF-C and the density of capillaries and lymphatic microves- sels.The relationship between the positive expression of VEGF-C and the tumor differentiation,lymph mode metastasis and pathlogical type was analyzed.The capillaries and lymphatic microvesscls were compared between the tumor tis- sues with and without lymph node metastasis and with positive and negative VEGF-C expression.Results The tumor tissue with lymph node metastasis had higher positive VEGF-C expression rate than the tumor tissue without lymph node metastasis （X2=15.461,P〈0.O5）;The positive VEGF-C expression rates in the NSCLC tissues with different differ- entiation degrees and different pathological types had no significant difference （P〉O.05）.The NSCLC tissues with posi- tive VEGF-C expression had larger lymphatic microvessel count than the tissues with negative VEGF-C expression （t= 22.080,P〈0.05）;The NSCLC tissues with lymph node metastasis had larger lymphatic microvessel count and capillary count than the NSCLC tissues without lymph node metastasis （t=37.312 and 20.847 respectively,P〈0.05）.Conclusion VEGF-C may promote the lymph node metastasis of NSCLC through regulating the number of lymphangiogenesis.