Technetium-99m benzimidazolyl iminodiacetic acid hepatobiliary radiopharmaceuticals: structure biodistribution studies |
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| Authors: | F C Hunt D J Maddalena J G Wilson |
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| Affiliation: | 1. Buchanan Ocular Therapeutics Unit, Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, New Zealand;2. Department of Ophthalmology and the New Zealand National Eye Centre, University of Auckland, New Zealand;3. Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, University of Auckland, New Zealand;4. School of Optometry and Vision Science and the New Zealand National Eye Centre, University of Auckland, New Zealand |
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| Abstract: | The biodistribution of fifteen structural variants of the hepatobiliary radiopharmaceutical, technetium-99m benzimidazolyl iminodiacetic acid (BIMIDA) were determined 1 h after i.v. injection into rats. The best compounds with respect to hepatobiliary excretion were those with halogen substituents in the benzene ring of the BIMIDA ligand. The cholescintigraphic properties of the BIMIDA compounds compared favourably with those of technetium-99m acetanilido iminodiacetic acid (HIDA) radiopharmaceuticals. |
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