| 长链非编码RNA MALAT1在乳腺癌中的研究现状 |
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| 引用本文： | 宋丹丹,陈雪源,陈瑞琪,李涵乔,吴甜. 长链非编码RNA MALAT1在乳腺癌中的研究现状[J]. 中国临床药理学与治疗学, 2021, 0(1) |
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| 作者姓名： | 宋丹丹 陈雪源 陈瑞琪 李涵乔 吴甜 |
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| 作者单位： | 中南大学湘雅三医院;中南大学湘雅医学院;中南大学湘雅药学院 |
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| 基金项目： | 湖南省自然科学基金项目(2020JJ5870);中南大学大型仪器共享基金项目(CSUZC201936)。 |
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| 摘 要： | 长链非编码RNA(long non-coding RNA,LncRNA)是一类长度大于200nt的RNA分子,其异常表达在多种肿瘤的发生发展中起重要作用。肺腺癌转移相关转录本1(metastasis-associated lung adenocarcinoma transcript 1,MALAT1)是LncRNA的一种,与乳腺癌的发生密切相关,可影响乳腺癌的发生发展,有望成为诊断和治疗乳腺癌的有效靶点。本文就MALAT1在乳腺癌的研究现状进行梳理,旨在为MALAT1在新药研发和临床实践中的应用提供参考。
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| 关 键 词： | 乳腺癌 长链非编码RNA 肺腺癌转移相关转录本1 |
Research status of long non-coding RNA MALAT1 in breast cancer |
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| SONG Dandan,CHEN Xueyuan,CHEN Ruiqi,LI Hanqiao,WU Tian. Research status of long non-coding RNA MALAT1 in breast cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 0(1) |
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| Authors: | SONG Dandan CHEN Xueyuan CHEN Ruiqi LI Hanqiao WU Tian |
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| Affiliation: | (The Third Xiangya Hospital,Central South University,Changsha 410013,Hunan,China;Xiangya Medical College of Central South University,Changsha 410013,Hunan,China;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,Hunan,China) |
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| Abstract: | Long non-coding RNA(LncRNA)is a kind of RNA longer than 200nt,whose abnormal expression plays a significant role in the development of tumors.Metastasis-associated lung adenocarcinoma transcription 1(MALAT1),as one of LncRNAs,is closely related to the pathogenesis of breast cancer.MALAT1 can affect the tumorigenesis and progression of breast cancer and is expected to be an effective target for the diagnosis and treatment of breast cancer.Herein,we review the research status of MALAT1 in breast cancer. |
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| Keywords: | breast cancer long non-coding RNA metastasis-related transcript 1 of lung adenocarcinoma |
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