A retrospective study of papillary thyroid carcinoma: Hashimoto's thyroiditis as a protective biomarker for lymph node metastasis |
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| Affiliation: | 1. School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, PR China;2. State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083, PR China;1. Department of Computer Science, University of North Carolina at Chapel Hill, United States;2. Department of Physics and Astronomy, Michigan State University, United States;3. Department of Computer Science, North Carolina State University, United States;4. Department of Computer Science, University of North Carolina at Chapel Hill, CB #3175, Sitterson Hall, Chapel Hill, NC 27599-3175, United States;1. General Surgery Department, Peking Union Medical College Hospital, Beijing, 100730, China;2. Ultrasonography Department, Peking Union Medical College Hospital, Beijing, 100730, China;3. Institute of Basic Medical Sciences, Chinese Academy of Medical Science, School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China;1. Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea;2. Department of Health Sciences and Technology, Graduate School, Samsung Advanced Institute of Health Science and Technology, Sungkyunkwan University, Seoul, Korea;3. Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea;1. Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA;2. University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA |
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| Abstract: | ![]()
PurposeThere is approximately 10%–50% of papillary thyroid carcinoma (PTC) patients with Hashimoto's thyroiditis (HT). In this research, we sought to better understand the role of HT in PTC progression as well as lymph node metastasis.MethodsIt is a retrospective and cross-sectional study, and 4131 PTC patients who underwent thyroidectomy were finally enrolled. Chi-square test, univariate and multivariate logistic regression analyses were employed to evaluate both the risk factors and the critical roles of HT during PTC metastasis.ResultIn this cohort, 1555 patients (37.6%) were diagnosed with HT. According to multivariate analysis, male sex, high levels of TG and TPOAb, tumor extrathyroidal extension, maximum diameter >1 cm, and multifocality were independent risk factors for both central lymph node metastasis (CLNM) and lateral lymph node metastasis (LLNM). In addition, age <55 years and smoking were risk factors for CLNM, while CLNM was one of the risk factors for LLNM. Furthermore, HT was suggested a valuable protective factor for both CLNM and LLNM. In patients with HT, the total number of central lymph nodes was higher, while the positive rate was lower. Compared with those without HT, age and sex did not predict CLNM and LLNM in patients with HT.ConclusionHT is considered a protective factor for both CLNM and LLNM in PTC. For patients with HT, surgeons should pay more attention to the preservation of parathyroid gland and the protection of recurrent laryngeal nerve due to less lymph node metastasis. Otherwise, radical operation is highly recommended. |
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| Keywords: | Papillary thyroid carcinoma Hashimoto's thyroiditis Central lymph node metastasis Lateral lymph node metastasis Risk factor |
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