| 巨噬细胞移动抑制因子在动脉粥样硬化中的研究进展 |
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| 引用本文： | 张韶辉,高东升. 巨噬细胞移动抑制因子在动脉粥样硬化中的研究进展[J]. 国外医学:内科学分册, 2009, 36(9): 524-527 |
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| 作者姓名： | 张韶辉 高东升 |
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| 作者单位： | 天津医科大学,天津,300070;济宁医学院附属医院心内科,山东,济宁,272029 |
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| 摘 要： | 巨噬细胞移动抑制因子（MIF）是一种高度保守的的多能细胞因子,受下丘脑一垂体控制,在调节机体固有免疫和获得性免疫中发挥重要作用。MIF在机体中分布广泛,并参与了多种疾病的发生和发展过程。近年来MIF在动脉粥样硬化中的作用倍受关注,研究证实MIF参与了动脉粥样硬化的发生、发展及演化过程。虽然大多数研究承认MIF与冠状动脉性心脏病之间存在相关性,但仍存在许多争议,其与冠状动脉性心脏病的相关性研究目前仍处于起步阶段。
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| 关 键 词： | 巨噬细胞移动抑制因子 动脉粥样硬化 冠状动脉性心脏病 |
Progression of macrophage migration inhibitory factor in atherosclerosis |
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| ZHANG Shao-hui,GAO Dong-sheng. Tianjin Medical University,Tianjin ,China. Progression of macrophage migration inhibitory factor in atherosclerosis[J]. Foreign Medical Sciences(Section of Internal Medicine), 2009, 36(9): 524-527 |
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| Authors: | ZHANG Shao-hui GAO Dong-sheng. Tianjin Medical University Tianjin China |
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| Affiliation: | ZHANG Shao-hui1,GAO Dong-sheng2.1 Tianjin Medical University,Tianjin 300070,China,2 Department of Cardiology,the Affiliated Hospital of Jining Medical College,Jining 272029 |
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| Abstract: | Macrophage migration inhibitory factor(MIF)is a highly conservative and multipotent cytokines,which is widely distributed in the body and play an important role in the regulation of innate immunity and acquired immunity under the control of the hypothalamus-pituitary.MIF may be involved in a variety of physiological and pathological responses.Recent years,the role of MIF played in atherosclerosis was paid more attention to.Researches showed that MIF participated in the development and evolution of atheroscl... |
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| Keywords: | Macrophage migration inhibitory factor Atherosclerosis Coronary heart disease |
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