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Brain somatostatin receptor subpopulation visualized by autoradiography
Authors:R. Maurer  J.C. Reubi
Affiliation:1. Physics in Biology and Medicine Interdepartmental Graduate Program, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;2. Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;3. Department of Molecular & Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;4. Ahmanson Translational Imaging Division, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;5. Department of Nuclear Medicine, University of Würzburg, Würzburg, Germany;6. Jonsson Comprehensive Cancer Center (JCCC), UCLA, Los Angeles, CA, USA;7. Department of Chemistry, University of British Columbia, Vancouver, BC, Canada
Abstract:
[125I-Tyr11]somatostatin-14 as well as iodinated D-Tyr1 and Tyr3 derivatives of the cyclic octapeptide somatostatin analog, SMS 201-995 (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol) have been used as radioligands for somatostatin receptor autoradiography in rat brain. Although the cyclic octapeptide ligands label the majority of the regions labeled with [125I-Tyr11]somatostatin, in the cortex and hippocampus only a subpopulation of somatostatin receptors is labeled. Cyclic octapeptide ligands have improved resolution due to their very low non-specific binding.
Keywords:somatostatin   subpopulation   receptor   rat brain   autoradiography   SMS 201–  995 analogs
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