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| 等容大鼠心脏机械功能与能量代谢的同步观测 | |
| 引用本文： | 程增江,杜泽涵,李红昕,董华进,冯锐,李光玉.等容大鼠心脏机械功能与能量代谢的同步观测[J].军医进修学院学报,1999,0(2):120-122. |
| 作者姓名： | 程增江 杜泽涵 李红昕 董华进 冯锐 李光玉 |
| 作者单位： | 1. 解放军总医院微量元素研究室,北京,100853 2. 军事医学科学院国家生物医学分析中心,北京,100850 3. 山东省立医院心外科,济南,250021 4. 军事医学科学院毒物药物研究所 |
| 基金项目： | “九五”军队卫生科研基金 |
| 摘 要： | 在核磁共振谱仪上建立对同一大鼠心脏机械功能与能量代谢同时测定的技术方法。方法制备离体等容大鼠心脏模型。通过建立计算机心监测系统测量和分析心脏的血流动力学参数；利用心脏的磷－３１核磁共振谱观测心肌组织的能量代谢。 |
| 关 键 词： | 核磁共振 离体心脏 血流动力学 |
Simultaneous observations of hemodynamics and energymetabolism in isovolumic rat heartmodel |
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| Cheng Zengjiang,Du Zehan,Li Hongxin,Dong Huajin,Feng Rui,Li Guangyu.Simultaneous observations of hemodynamics and energymetabolism in isovolumic rat heartmodel[J].Academic Journal of Pla Postgraduate Medical School,1999,0(2):120-122. | |
| Authors: | Cheng Zengjiang Du Zehan Li Hongxin Dong Huajin Feng Rui Li Guangyu |
| Abstract: | Objective:To establish a technique for simultaneous observations of mechanical functions and energy metabolic status in the isolated rat heart model.Methods: Isolated isovolumic rat heart models were prepared, heart hemodynamic parameters were determined and processed by means of establishing a computerized heart function monitoring system, and myocardial energy metabolism was investigated by collecting 31 P NMR spectra.Results: By establishing the NMR isovolumic rat heart preparation, the mechanical and metabolic functions of the heart were sequentially observed on real time, and all the hemodynamic and myocardial energy metabolic data could be obtained just after the experiments finished. Meanwhile ,the heart preparations were found to be stable under the NMR experimental conditions. Conclusion: The established isovolumic rat heart preparations for simultaneous NMR and hemodynamic determinations may provide advanced techniques that are very useful for domestic findamental researches in cardiovascular medicine. |
| Keywords: | NMR isolated heart hemodynamics |
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