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Demonstration of Communication between Alveolus and Interstitium in Persistent Interstitial Pulmonary Emphysema: Case Report |
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| Authors: | Jorge L. Yao Maria Fasano Raffaella Morotti Martha Caprio M. Alba Greco |
| Affiliation: | (1) Department of Pathology, Brooklyn Hospital, 121 DeKalb Avenue, Brooklyn, NY 11201, USA , US;(2) Department of Pathology, New York University/Bellevue Hospital, 560 First Avenue, New York, NY 10016, USA , US;(3) Department of Pediatrics, New York University/Bellevue Hospital, 560 First Avenue, New York, NY 10016, USA , US;(4) Kaplan Comprehensive Cancer Center, New York University, 550 First Avenue, New York, NY 10016, USA , US |
| Abstract: | Persistent interstitial pulmonary emphysema (PIPE) is an uncommon complication of premature infants suffering from hyaline membrane disease who have been treated with mechanical ventilation. The presumed mechanism for the development of the disease is via a break in the bronchioalveolar system that allows air to escape into the interstitium. We report a case of a 9-week-old child who developed the localized form of the disease and underwent a lobectomy. Immunohistochemical stains helped to demonstrate the communication between the airway system and interstitium. This report strengthens the theory that the disease develops from airway rupture at the alveolar level. Received August 17, 1998; accepted November 16, 1998. |
| Keywords: | : emphysema hyaline membrane disease immunohistochemistry keratin lung premature |
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