比格犬肝脏自发病变的组织学研究

为了解比格犬脏器自发病变的发生情况，以建立应用于GLP的比格犬自发病变的病理图谱。采用组织学技术结合临床检验，分析了10～18月龄的60例比格犬肝脏的组织病理变化和肝功能指标。结果发现，7项肝功能指标均有不同程度偏差。63．3％的比格犬肝脏存在不同性质和程度的组织学病变。包括实质细胞的各种退行性变化、不同程度的坏死和增生，结缔组织的增生和纤维化，炎性细胞浸润，脓肿、囊肿等共20种病变。肝脏病变程度和发生率与性别无关，同一个体肝脏病变的种类数平均约3种。结果提示，应加强实验动物自发病变的病理监测，为药物安全性评价试验提供受试动物自发性病变的基本资料。

Histopathology Observation on Liver Spontaneous Lesions in Beagle Dogs

To detect the liver spontaneous lesions of beagle dogs used in toxicity studies. Sixty beagle dogs from control experimental groups, age from 10-18 months were used. Liver fune-tion index of serum were tested and liver samples were observed by routine histological tech-nique. The results revealed that all 7 clinical index were deviated in different degree. Various spontaneous lesions amounting to 20 kinds in different degrees were found in 63. 3% dogs of the study, ineluding hepatocyte degenerations, necroses,and proliferations, connective fiber proliferations and fibrosis ,inflammatory cell infiltration ,abscess and cystis. The degree and the frequen cy of lesions was no difference between the sex. Usually several kinds of lesions occurred in the liver of one dog. It is suggested that spontaneous lesions should be monitored so as to provide histopathological investigations for safety estimation experiment of new medicine.