|
|||||
|
|
| 盐酸多奈哌齐联合尼麦角林治疗血管性认知功能障碍临床观察 | |
| 引用本文： | 孙佳斌,范学文,梁华敏,毕鹏翔. 盐酸多奈哌齐联合尼麦角林治疗血管性认知功能障碍临床观察[J]. 牡丹江医学院学报, 2012, 33(2): 12-14 |
| 作者姓名： | 孙佳斌 范学文 梁华敏 毕鹏翔 |
| 作者单位： | 1. 宁夏医科大学 宁夏银川 750004 2. 宁夏医科大学附属医院 宁夏银川 750004 3. 牡丹江医学院附属红旗医院神经内科 黑龙江牡丹江 157011 |
| 摘 要： | 目的:探讨盐酸多奈哌齐联合使用尼麦角林用于血管性认知功能障碍患者的治疗效果。方法:选取选血管性认知功能障碍患者98例,将其随机分为盐酸多奈哌齐合用尼麦角林治疗组(32例)及盐酸多奈哌齐治疗组(36例),未使用改善认知功能药物对照组(30例)在治疗前对其使用MOCA量表评分,并于12周以后对患者随访时再次进行MOCA量表及ADL评分的结果为评价疗效。结果:盐酸多奈哌齐联合尼麦角林治疗组与单纯盐酸多奈哌齐治疗组患者在治疗后比较对照组认知功能改善及生活能力评分相比差异均有统计学意义(p<0.05)。联合治疗组与盐酸多奈哌齐组相比认知功能改善差异具有统计学意义(p<0.05)。结论:盐酸多奈哌齐及盐酸多奈哌齐申联合尼麦角林均可以改善血管性认知功能障碍患者的认知功能;且盐酸多奈哌齐联合尼麦角林临床效果更加明显。 |
| 关 键 词： | 盐酸多奈哌齐 尼麦角林 血管性认知功能障碍 |
EFFICACY OF DONEPEZIL COMBINED WYTH NICERGOLINE IN TREATMENT OF VASCULAR COGNITIVE IMPAIRMENT |
|
| Affiliation: | Sun Jia bin et al(Ningxia Medical Vnivev sing Yinchuan 750004,China) |
| Abstract: | Objective:To study the therapeutic effect of nicergoline and donepezil treatment patient with vascular cognitive impairment on cognitive function.Methods:98 patients with vascular cognitive impairment were randomly divided into 3 groups,one of them treatd with donepezil combined with nicergoline group(32patients),the group treatd with donepezil(36parients),and the control group does not ues any medicine which could improve cognitive function.MoCA Scale and ADL Scale of all groups were assessed and compared before the treatment and 12-weeks treatment after.Results:The combine medicine group and the single medicine group were improved markedly(p<0.01).The behavioral abilities were improved markedly(p<0.05)in the group treated with donepezil combined with nicergoline.Conclusion:Combination of donepezil and nicergolin can markedly ameliorate the cognitive function and behavioral ability in patients with vascular cognitive impairment. |
| Keywords: | Donepezil Nicergoline Vascular cognitive impairment |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |