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| 表皮生长因子受体在小鼠磨牙牙胚发育过程中的表达及其生物学意义 | |
| 引用本文： | 朱奇,于涌,樊明文,边专,陈智,彭彬. 表皮生长因子受体在小鼠磨牙牙胚发育过程中的表达及其生物学意义[J]. 口腔医学研究, 2006, 22(4): 360-363 |
| 作者姓名： | 朱奇 于涌 樊明文 边专 陈智 彭彬 |
| 作者单位： | 武汉大学口腔医学院教育部口腔生物医学工程重点实验室,湖北,武汉,430079;湖北省浠水清泉医院口腔科 |
| 摘 要： | 目的:探讨表皮生长因子受体在小鼠磨牙牙胚发育过程中的生物学作用。方法:用免疫组织化学检测表皮生长因子受体(EGFR)在小鼠下颌第一磨牙牙胚发育过程中的定位。结果:证实EGFR在鼠牙胚不同发育阶段呈时间-空间特异性分布模式。EGFR特别地在细胞增殖活跃的部位强染,在形态发生和分化晚期染色减弱。结论:EGF及其受体可能在调控蕾状期和帽状期形态发生的上皮-间充质相互作用中以旁分泌模式起作用。 |
| 关 键 词： | 表皮生长因子受体 牙胚 发育 |
| 文章编号： | 1671-7651(2006)04-0360-04 |
| 修稿时间： | 2006-06-10 |
Immunolocalization of Epidemal Growth Factor Receptor during Mouse Molar Development |
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| ZHU Qi,YU Yong,FAN Ming-wen,et al.. Immunolocalization of Epidemal Growth Factor Receptor during Mouse Molar Development[J]. Journal of Oral Science Research, 2006, 22(4): 360-363 | |
| Authors: | ZHU Qi YU Yong FAN Ming-wen et al. |
| Affiliation: | ZHU Qi,YU Yong,FAN Ming-wen,et al.Key Laboratory for Oral Biomedical Engineering,Ministry of Education,School of Stomatology,Wuhan University,Wuhan 430079 |
| Abstract: | Objective: To study the biological roles of epidemal growth factor receptor(EGFR) during mouse molar development.Methods: Immunohistochemistry was used to examine the immunolocalization of EGFR during mouse first lower molar development.Results: The results showed that EGFR was immunolocalized during mouse molar development in a temporally and spatially regulated fashion.EGFR was especially stong stained where cell actively proliferated and stained weakly during late stage of tooth morphogenesis and differentiation.Conclusion: EGFR is suggested to be involved in a paracrine fashion in the epithelial-mesenchymal interactions regulating morphogenesis of bud-and cap-stage teeth. |
| Keywords: | Epidemal growth factor receptor Tooth germ Development |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |