| 人类白细胞抗原等位基因与慢性乙型肝炎聚乙二醇化干扰素疗效的相关性研究 |
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| 引用本文： | 冯彦,丛书英. 人类白细胞抗原等位基因与慢性乙型肝炎聚乙二醇化干扰素疗效的相关性研究[J]. 中华实验和临床感染病杂志(电子版), 2008, 2(4): 300-303 |
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| 作者姓名： | 冯彦 丛书英 |
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| 作者单位： | 1. 青岛大学,青岛市,266021
2. 青岛市传染病医院 |
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| 摘 要： | 目的 探讨人类白细胞抗原(HLA)-DRB1等位基因与聚乙二醇化干扰素(PEG-IFN)抗HBV应答的相关性.方法 应用聚合酶链反应-序列特异性引物(PCR-SSP)技术对青岛地区46例慢性乙型肝炎患者HLA-DRB1进行等位基因多态性分析.结果 30例有应答者HLA-DRB1*15等位基因频度(46.67%)高于16例无应答者(12.5%),RR=6.125,P=0.021; HLA-DRB1*07的分布则相反(26.67%对75%,RR=0.121,P=0.002).结论 推测HLA-DRB1*15可能与PEG-IFN的高应答有关, HLA-DRB1*07可能与PEG-IFN低应答有关.
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| 关 键 词： | 慢性乙型肝炎 HLA-DRB1等位基因 干扰素 |
Association of HLA-DRB1 alleles with response to PEG-interferon therapy in chronic hepatitis B |
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| FENG Yan,CONG Shu-ying. Association of HLA-DRB1 alleles with response to PEG-interferon therapy in chronic hepatitis B[J]. Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Version), 2008, 2(4): 300-303 |
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| Authors: | FENG Yan CONG Shu-ying |
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| Affiliation: | FENG Yan CONG Shu-ying |
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| Abstract: | Objective To appraise the influence of human leukocyte antigen (HLA)-DRB1 alleles on response to interferon (PEG-IFN) therapy in chronic hepatitis B.Methods Polymerase chain reaction-sequence specific primers (PCR-SSP) technique was used to determine HLA-DRB1 genes in 46 patients of Qingdao with chronic hepatitis B.Results The frequency of HLA-DRB1*15 allele was higher in 30 IFN responders than that in 16 non-responders (46.67% vs 12.50%,RR=6.125,P=0.021),whereas that of DRB1*07 alleles distribution was on ... |
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| Keywords: | Chronic hepatitis B Human leukocyte antigen-DRB1 alleles Interferon |
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