| 环状RNA研究进展及临床应用 |
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| 引用本文： | 孔德沛,訾晓渊,孙颖浩. 环状RNA研究进展及临床应用[J]. 第二军医大学学报, 2016, 37(3): 330-335. DOI: 10.16781/j.0258-879x.2016.03.0330 |
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| 作者姓名： | 孔德沛 訾晓渊 孙颖浩 |
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| 作者单位： | 第二军医大学长海医院泌尿外科,上海,200433 |
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| 基金项目： | 孔德沛;硕士生.E-mail:346049188@qq.com |
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| 摘 要： | 环状RNA(circular RNA,circRNA)是一类产生于RNA剪切过程的封闭环形RNA分子,主要由外显子和(或)内含子构成,广泛存在于真核细胞内,具有稳定性、物种保守性以及细胞、组织特异性.环状RNA参与细胞内RNA调控网络,与疾病的发生和发展密切相关,可能成为新型的生物标记物及治疗靶点.近年来,关于环状RNA产生、调控、生物学特性、功能及其与疾病的关系等均取得了较大的研究进展.本文综述了真核细胞内源性环状RNA的研究进展及其与疾病的关联.
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| 关 键 词： | 环状RNA 生成 特性 疾病 生物学标记 |
| 收稿时间： | 2016-02-03 |
| 修稿时间： | 2016-03-10 |
circRNA: research progress and clinical applications |
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| KONG De-pei,ZI Xiao-yuan and SUN Ying-hao. circRNA: research progress and clinical applications[J]. Former Academic Journal of Second Military Medical University, 2016, 37(3): 330-335. DOI: 10.16781/j.0258-879x.2016.03.0330 |
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| Authors: | KONG De-pei ZI Xiao-yuan SUN Ying-hao |
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| Affiliation: | Second Military Medical University,Second Military Medical University,Second Military Medical University |
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| Abstract: | circular RNAs (circRNAs) are a newly rised species of RNAs with covalently closed loop structure and are wildly expressed in eukaryocyte. Consisting of exons and/or introns, circRNAs are generated during the process of RNA splicing and found to be relatively stable, evolutionally conserved and tissue/cell-specific. A few studies have indicated that circRNAs may participate in the RNA-RNA regulation network or RNA-protein complex formation and thus are involved in a diversity of diseases including cancer. Here we review the currently available outcomes of circRNAs related research and discuss the promising future of circRNAs. |
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| Keywords: | circRNA biogenesis property disease biomarker |
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