Transplantation of adrenal tissue into the central nervous system

Adrenal medullary tissue can survive transplantation to the central nervous system. Such survival has been obtained experimentally with grafts to the anterior eye chamber, to the brain and to the spinal cord, using medullary tissue from the recipient animal or unrelated animals of the same or, in some cases, different species. Appropriately placed grafts have been shown, under certain conditions, to interact with the host nervous system, exerting behavioral effects including amelioration of experimentally-induced parkinsonian symptoms. Such effects may be enhanced by administration of nerve growth factor to the grafts. On the basis of such findings, adrenal medullary tissue has been grafted to the brain of Parkinson's disease patients. Both animal and human experiments raise important questions about mechanisms of graft action and about factors that influence the outcome of these procedures.