乳腺癌组织中Ang-2和受体Tie2的表达及与血管生成的关系

目的：探讨Ang-2和Tie2的表达与乳腺癌浸润和转移的关系。方法：选用42例乳腺癌标本、16例乳腺纤维腺瘤及13例正常乳腺组织，以SP法进行Ang-2、Tie2及CD34标记的微血管密度（MVD）的检测，并分析其与临床病理特征的关系。结果：在乳腺癌组织中，Ang-2、Tie2阳性表达率分别为95．2％和92．9％；明显高于正常乳腺组织（15．4％、12．5％）和乳腺纤维腺瘤组织（15．4％，15．4％），P=0．001。CD34标记的MVD与Ang-2、Tie2密切相关。结论：人乳腺癌中血管生成增加，Ang-2和Tie2在乳腺癌血管生成和进展中可能起重要作用。

Expression of Ang-2/Tie2 and its relation with angiogenesis in breast carcinoma

OBJECTIVE:To study the expressions of Ang-2 and Tie2 in breast cancer and the relation with invasion and metastasis.MEHTODS: The immunohistochemical technique SP was used to detect the Ang-2,Tie2 and MVD which was marked by CD34 in 42 cases of breast cancer,16 cases of breast fibroadenoma and 13 cases of normal breast,the associations between their expressions and the features of clinical pathology of invasive ductal breast carcinoma were also analyzed.RESULTS: The positive rates of Ang-2 and Tie2 in malignant breast tumor were 95.2% and 92.9%,much higher than those in normal breast and breast fibroadenoma which were 15.4%,15.4% and 12.5%,12.5%,P=0.001.There were close correlations between Ang-2 and CD34,Tie2 and CD34.CONCLUSIONS: Angiogenesis is enhanced in breast carcinoma.Ang-2/Tie2 may play a critical role in promoting tumor angiogenesis and progression in human breast carcinoma.