| 重度子痫前期产妇血清和胎盘组织中脂蛋白脂酶的表达及意义 |
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| 引用本文： | 程淑清,黄亚绢,范琦慧. 重度子痫前期产妇血清和胎盘组织中脂蛋白脂酶的表达及意义[J]. 实用妇产科杂志, 2011, 27(2) |
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| 作者姓名： | 程淑清 黄亚绢 范琦慧 |
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| 作者单位： | 1. 浙江省宁波市妇女儿童医院,浙江,宁波,315012
2. 上海交通大学医学院附属第六人民医院,上海,200233 |
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| 摘 要： | 目的:探讨脂蛋白脂酶(LPL)在重度子痫前期产妇血清和胎盘组织中的表达及意义。方法:收集2008年9月至2009年5月在上海市第六人民医院产科住院并分娩的重度子痫前期产妇26例为子痫前期组,选择同期分娩的正常产妇30例为对照组。用酶法检测血脂浓度,ELISA法检测血清LPL浓度,RT-PCR法和Western blot法检测胎盘组织LPL基因和蛋白的表达。结果:①子痫前期组血脂浓度明显高于对照组(P<0.05)。②子痫前期组血清LPL浓度及胎盘组织LPL基因和蛋白表达水平均明显低于对照组(P<0.05)。③子痫前期组血清LPL浓度与胎盘组织LPL蛋白表达水平呈正相关(r=0.421,P<0.05),与甘油三酯(TG)呈负相关(r=-0.668,P<0.01),与高密度脂蛋白(HDL)呈正相关(r=0.876,P<0.01)。结论:子痫前期患者机体脂蛋白脂酶表达降低,脂蛋白脂酶可能通过参与高血脂代谢在子痫前期发病过程中起着重要作用。
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| 关 键 词： | 子痫前期 脂蛋白脂酶 血脂 血清 胎盘组织 |
Expression and Significance of Lipoprotein Lipase in Serum and Placenta with Severe Preeclampsia |
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| CHENG Shuqing,HUANG Yajuan,FAN Qihui. Expression and Significance of Lipoprotein Lipase in Serum and Placenta with Severe Preeclampsia[J]. Journal of Practical Obstetrics and Gynecology, 2011, 27(2) |
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| Authors: | CHENG Shuqing HUANG Yajuan FAN Qihui |
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| Affiliation: | CHENG Shuqing1,HUANG Yajuan2,FAN Qihui1(1. NingBo Women and Children's Hospital,Ningbo Zhejiang 315012,China,2. The Sixth People Hospital of Shanghai,Affiliated to Medical Collage of Shanghai Jiao Tong University,Shanghai 200233,China) |
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| Abstract: | objective:To investigate the expression and significance of lipoprotein lipase (LPL) in serum and placenta with severe preeclampsia. Methods:26 cases of severe preeclampsia pregnancies and 30 normal pregnancies were enrolled from Sep. 2008 to May 2009 in the Sixth People Hospital of Shanghai. The levels of Lipids and LPL in Serum were determined by enzymic method and ELISA respectively. The levels of LPLmRNA and protein in placenta were detected by RT-PCR and Western blot respectively. Results:The levels of... |
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| Keywords: | Preeclampsia Lipoprotein lipase Lipids Serum Placenta |
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