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| 白介素-4和白介素-8在高原地区慢性肺心病发病机制中的作用和临床意义 | |
| 引用本文： | 杨生岳,沈君礼,冯恩志,郭振援,黄宁侠,张瑛,陈宗茹,种银侠,张花. 白介素-4和白介素-8在高原地区慢性肺心病发病机制中的作用和临床意义[J]. 西北国防医学杂志, 2010, 31(1): 34-36 |
| 作者姓名： | 杨生岳 沈君礼 冯恩志 郭振援 黄宁侠 张瑛 陈宗茹 种银侠 张花 |
| 作者单位： | 解放军第四医院呼吸内科,青海,西宁,810007 |
| 摘 要： | 目的：探讨白介素-4（IL-4）和白介素-8（IL-8）在高原慢性肺心病发病机制中的作用和意义。方法：高原肺心病急性加重期患者66例、缓解期患者61例,健康对照组35例,分别测血清IL-4、IL-8、肺功能和血气。结果：肺心病急性加重期血清IL-4、IL-8、PaCO2高于缓解期,缓解期高于对照组（P均〈0.01）,急性加重期FEV1%、FEV1/FVC、PaO2低于缓解期,缓解期低于对照组（P均〈0.01）。急性加重期和缓解期血清IL-4、IL-8与FEV1%、FEV1/FVC、PaO2呈负相关,与PaCO2呈正相关（P均〈0.01）。结论：IL-4、IL-8参与了高原肺心病的气道炎症反应。检测血清IL-4、IL-8浓度变化可作为高原肺心病患者病情和疗效判断的有效指标。 |
| 关 键 词： | 肺疾病 阻塞性 肺心病 白介素-4 白介素-8 高原 |
Function and clinical significance of IL-4 and IL-8 in the patients with high altitude chronic cor pulmonale |
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| YANG Sheng-yue,SHEN Jun-li,FENG En-zhi,et al.. Function and clinical significance of IL-4 and IL-8 in the patients with high altitude chronic cor pulmonale[J]. Medical Journal of National Defending Forces in Northwest China, 2010, 31(1): 34-36 | |
| Authors: | YANG Sheng-yue SHEN Jun-li FENG En-zhi et al. |
| Affiliation: | YANG Sheng-yue,SHEN Jun-li,FENG En-zhi,et al.(Department of Respiratory Medicine,Fourth Hospital of PLA,Lanzhou Comm,,Xining 810007,China) |
| Abstract: | Objective:To investigate the function and clinical significance of IL-4 and IL-8 in the patients with high altitude chronic cor pulmonale(HACCP).Methods: Sixty-six patients at acute stage of HACCP and 61 patients at remission stage were included.Thirty-five healthy volunteers were used as controls.Their serous level of IL-4,IL-8,lung function and PaCO2 were measured.Results:The patients at acute stage had significantly higher serous IL-4 and IL-8 level and PaCO2 than the patients at remission stage(P<0.01).... |
| Keywords: | Lung disease obstructive Chronic cor pulmonale Interleukin-4 InterleukinL-8 High altitude |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |