血浆透析滤过与双重血浆分子吸附系统治疗肝衰竭患者的效果及对肝功能、炎症细胞因子和凝血功能的影响

目的 探讨血浆透析滤过(PDF)与双重血浆分子吸附系统(DPMAS)治疗肝衰竭患者疗效及对肝功能、炎症细胞因子和凝血功能指标的影响.方法 选取2017年5月至2020年5月在山东省立第三医院诊治的100例肝衰竭患者,按照随机数字法分为对照组(50例)和观察组(50例).对照组给予PDF治疗,观察组给予DPMAS治疗,比...

Curative effect of plasma diafiltration and dual plasma molecular adsorption system on patients with liver failure and their influences on liver function,inflammatory cytokines and coagulation function indexes

Objective To explore the curative effect of plasma diafiltration(PDF)and dual plasma molecular adsorption system(DPMAS)on patients with liver failure and their influences on liver function,inflammatory cytokines and blood coagulation indexes.Methods A total of 100 patients with liver failure treated in the hospital from May 2017 to May 2020 were enrolled and divided into control group(n=50)and observation group(n=50)according to random number table method.The control group was treated with PDF,while observation group was treated with DPMAS.The clinical curative effect,liver function indexesalanine transaminase(ALT),aspartic albumin(ALB),total bilirubin(TBIL),cholinesterase(CHE)],inflammatory cytokinesinterleukin-10(IL-10),transforming growth factor-β(TGF-β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)],coagulation function indexesprothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)],immune function and incidence of adverse reactions were compared between the two groups.Results The response rate of treatment in observation group was significantly higher than that in control group(76.0%vs.56.0%,P<0.05).Before treatment,there was no significant difference between the two groups in ALT,ALB,TBIL,CHE,IL-10,TGF-β,IL-6,TNF-α,CRP,PT,TT,APTT,CD4⁺,CD8⁺or CD4⁺/CD8⁺(P>0.05).After treatment,ALT,TBIL,IL-6,TNF-α,CRP,PT,TT,APTT and CD8⁺in observation group were significantly lower than those in control group,while ALB,CHE,IL-10,TGF-β,CD4⁺and CD4⁺/CD8⁺were significantly higher than those in control group(P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant(P>0.05).Conclusions Curative effect of DPMAS is significant on patients with liver failure.It can improve liver function and coagulation function,reduce levels of inflammatory factors,and improve immune function.