Serum MBP immunoreactivity and immunoglobulin level as markers of tumour type |
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| Authors: | PA Seeldrayers NR Hoyle DGT Thomas |
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| Affiliation: | (1) Department of Neurological Surgery, Institute of Neurology, WC1 Queen Square, London, UK;(2) Present address: Department of Neurology, Erasmus Hospital, Free University Brussels, Brussels, Belgium;(3) Department of Neurological Surgery, Institute of Neurology, WC1N 3BG Queen Square, London, UK |
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| Abstract: | ![]()
Summary Forty three patients, admitted to the department of Neurological Surgery for management of central nervous system tumours, were studied pre-operatively for serum myelin basic protein immunoreactivity as a marker of central nervous system lesion and for circulating immunoglobulins and complement (C3) levels. Myelin basic protein concentration did not appear to correlate with tumour type or grade. Serum immunoglobulin levels were found to be within the normal range but the mean IgM level was significantly higher in the glioma group when compared with meningiomas. |
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| Keywords: | intracranial tumour immunoglobulins myelin basic protein glioma tumour grade |
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