瘦素与胃排空

瘦素(leptin)是一种主要由白色脂肪组织分泌的蛋白类激素。在调节摄食、体重、能量消耗和神经内分泌方面发挥着重要的作用。最近研究表明,瘦素可以改变胃肠神经肌肉的反应性,调节胃排空。除了调节能量代谢平衡等作用,还有抑制摄食、抑制胃排空和调节胃肠激素的分泌作用。提示,瘦素是与胃肠的生理功能及胃肠疾病密切相关的一种新的胃肠激素。

Leptin and gastric emptying

Leptin is an adipocyte-derived hormone that plays a key role in the regulation of food intake, body weight, energy expenditure and neuroendocrine function. Recent study have shown that leptin can altered responses to neurotransmitter in an in vitro muscle bath and altered in vivo gastric emptying. in this article we review leptin and its receptor express and excrete way in the gastrointestinal and the regulation of gastric emptying.Leptin seems therefore deeply involved in the functional activities of the digestive tract.