当归注射液对慢性阻塞性肺疾病伴肺动脉高压患者近期疗效观察

目的：观察当归注射液对慢性阻塞性肺疾病（ＣＯＰＤ）伴肺功能高压患者血流动力学、血管收缩肽，肺功能和动脉血气的影响。方法：将６０例ＣＯＰＤ伴肺动脉高压患者随机分成治疗组和对照组。每组３０例，分别静脉滴注２５％当归注射液和５％葡萄糖注射液，１８０天为１个疗程，观察用药前后血流动力学、血浆内皮素－１（ＥＴ－１），血管紧张素Ⅱ（ＡＴ－Ⅱ），内源性洋地黄物质（ＥＤＦ），肺和动脉血气的变化。结果：静脉滴注２５

Observation on Short-Term Effects of Angelica Injection on Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension

OBJECTIVE: To study the effects of 25% Angelica sinensis injection on hemodynamics, endothelin-1 (ET-1), angiotensin-II (AT-II), endogenous digitalis-like factor (EDF), pulmonary function and arterial blood gas in the patients with chronic obstructive pulmonary disease (COPD) complicated pulmonary hypertension. METHODS: Sixty COPD patients complicated with pulmonary hypertension in remission stage were randomly divided into two groups, 30 cases in each. The Angelica group and the control group were treated with Angelica sinensis injection and 5% glucose injection (250 ml, intravenous dripping per day for 10 days) respectively. It was designed to investigate the changes of hemodynamics, ET-1, AT-II, EDF, pulmonary function and arterial blood gas. RESULTS: The levels of mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR), blood ET-1, AT-II and EDF were reduced by (18 +/- 5)%, (27 +/- 8)%, (20 +/- 6)%, (36 +/- 9)%, (38 +/- 11)% respectively, and PaO2 was increased in Angelica group (P < 0.05 or P < 0.01). There were insignificant differences of the above parameters in the control group, and no changes of pulmonary function in both groups. CONCLUSION: Twenty-five Percent of Angelica injection can improve pulmonary hemodynamics through influencing the metabolism of ET-1, AT-II and EDF as well as increase PaO2 of the body.