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The Rotterdam Study: 2018 update on objectives,design and main results
Authors:M. Arfan Ikram  Guy G. O. Brusselle  Sarwa Darwish Murad  Cornelia M. van Duijn  Oscar H. Franco  André Goedegebure  Caroline C. W. Klaver  Tamar E. C. Nijsten  Robin P. Peeters  Bruno H. Stricker  Henning Tiemeier  André G. Uitterlinden  Meike W. Vernooij  Albert Hofman
Affiliation:1.Department of Epidemiology,Erasmus Medical Center,Rotterdam,The Netherlands;2.Department of Internal Medicine,Erasmus Medical Center,Rotterdam,The Netherlands;3.Department of Neurology,Erasmus Medical Center,Rotterdam,The Netherlands;4.Department of Psychiatry,Erasmus Medical Center,Rotterdam,The Netherlands;5.Department of Cardiology,Erasmus Medical Center,Rotterdam,The Netherlands;6.Department of Radiology and Nuclear Medicine,Erasmus Medical Center,Rotterdam,The Netherlands;7.Department of Ophthalmology,Erasmus Medical Center,Rotterdam,The Netherlands;8.Department of Gastro-Enterology,Erasmus Medical Center,Rotterdam,The Netherlands;9.Department of Otolaryngology,Erasmus Medical Center,Rotterdam,The Netherlands;10.Department of Dermatology,Erasmus Medical Center,Rotterdam,The Netherlands;11.Department of Respiratory Medicine,Erasmus Medical Center,Rotterdam,The Netherlands;12.Department of Respiratory Medicine,Ghent University Hospital,Ghent,Belgium;13.Department of Epidemiology,Harvard T. H. Chan School of Public Health,Boston,USA
Abstract:
The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.
Keywords:
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