异甘草酸镁治疗伴高胆红素血症病毒性肝炎的疗效观察

目的 评价异甘草酸镁治疗伴高胆红素血症病毒性肝炎的临床疗效。方法 将117例伴高胆红素血症病毒性肝炎患者随机分为两组，除普通治疗外，治疗组加用异甘草酸镁治疗，检测两组患者治疗前后血清生化学指标。结果 异甘草酸镁治疗伴高胆红素血症病毒性肝炎4周后，治疗组总有效率为82.5%，优于对照组的70.4%（P=0.004）；随访4周后，治疗组总有效率为88.9%，明显优于对照组的53.7%（P<0.001）。异甘草酸镁具有抗肝纤维化作用且无明显不良反应。结论 异甘草酸镁可以有效治疗伴高胆红素血症的病毒性肝炎。

Clinical efficacy of magnesium isoglycyrrhizinate in the management of virus hepatitis with hyperbilirubinemia

Objective    To evaluate the clinical efficacy of magnesium isoglycyrrhizinate in the management of virus hepatitis with hyperbilirubinemia. Methods    117 patients with virus hepatitis with hyperbilirubinemia were randomly divided into the therapy group and the control group. Besides routine therapy, patients in the therapy group received management of magnesium isoglycyrrhizinate. The serum biochemical parameters were determined in all patients at the onset and end of treatment. Results    Four weeks after the treatment, the total effective response was 82.5% in the therapy group and 70.4% in the control group with a significant difference (P=0.004). After four week follow up, the total effective response was 88.9% in the therapy group and 53.7% in the control group with a significant difference (P<0.001). The treatment with magnesium isoglycyrrhizinate was effective in reducing liver fibrosis and without significant side effects. Conclusion    Magnesium isoglycyrrhizinate is effective for virus hepatitis with hyperbilirubinemia.