中性粒细胞与淋巴细胞计数比值在呼吸道感染性疾病中的应用价值

目的探讨中性粒细胞与淋巴细胞比值（neutrophil—to-lymphocyte ratio，NLR）在呼吸道感染性疾病中的应用价值。方法对116例呼吸科发热待查的患者进行血常规检测，记录白细胞总数，中性粒细胞、淋巴细胞绝对值，计算NLR；并连续进行痰培养及血培养。结果细菌感染阳性组与阴性组WBC、Neu无显著性差异（P〉0．05），Lym、NLR有显著性差异（P〈0．01）。NCR的敏感性、特异性、阳性预测值、阴性预测值为各组最高（74％、62％、66％、71％）；Lym（62％、59％、60％、61％）；WBC（48％、53％、51％、51％）；Neu（43％、57％、50％、50％）。NCR组ROC曲线下面积最大（0．706）；Lym（0．530）；WBC（0．487）；Neu（0．324）。结论NLR对早期预测呼吸道细菌感染性疾病具有重要价值，可为临床早期合理用药提供帮助。

The Value of Neutrophil and Lymphocyte Count Ratio in the Respiratory Infections

Objective To investigate the value of neutrophil and lymphocyte count ratio（neutrophil-to- lymphocyte ratio,NLR） as a predictor of bacteremia in the respiratory infections.Methods 116 cases of patients with fever of unknown origin were in the Department of Respiratory for testing the blood routine,and recording the total count of white blood cells,neutrophils,lymphocytes and calculation of the NLR,sputum culture and blood culture consecutivily.Results Significant differences between patients with positive and negative groups were detected with respect to the lymphocyte count and NLR（P 〈 0.01）,but not regarding WBC count and neutrophil count（P 〉 0.05）.Sensitivity, specificity, positive and negative predictive values were highest for the NLR（74%,62%,66% and 71%,respectively）;Lym（62%,59%,60% and 61%,respectively）;WBC（48%,53%,51% and 51%,respectively）;Neu（43%,57%,50% and 50%,respectively）.The area under the receiver operating characteristic curve was highest for the NLR（0.706;confidence interval：0.611 -0.800）;lymphocyte count（0.530;0.424 0.636）;WBC（0.487;0.380 - 0.595）;neutrophil count（0.324;0.227 - 0.422）.Conclusion NLR for early prediction of respiratory bacterial infections are better than routine parameters like WBC count,neutrophil count,and lymphocyte count.