Switch of cadherin expression as a diagnostic tool for Leydig cell tumours |
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| Authors: | F Bremmer S Schweyer M Martin‐Ortega B Hemmerlein A Strauss HJ Radzun CL Behnes |
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| Affiliation: | 1. Department of Pathology, University Medical Centre G?ttingen, , Germany;2. Department of Urology, University Medical Centre G?ttingen, , Germany |
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| Abstract: | Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis with Leydig cell hyperplasia and Leydig cell tumours for their expression pattern of P‐ and N‐cadherin. We could show a switch of expression of P‐ and N‐cadherin in Leydig cell hyperplasia and Leydig cell tumours in comparison with normal Leydig cells. Cadherins could be established as a new immunohistochemical marker for this testicular tumour entity; their possible role in tumour genesis will be discussed. |
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| Keywords: | Leydig cell tumours P‐cadherin N‐cadherin cadherin switching Immunohistochemistry |
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