PREDICTION OF NON-SENTINEL LYMPH NODE METASTASES IN BREAST CANCER |
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| Authors: | Zhang Jie Shen Kunwei Lamichhane Nirmal Liu Guangyu Wu Jiong Shao Zhimin Shen Zhenzhou |
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| Affiliation: | Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032;Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032;Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032;Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032;Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032;Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032;Department of Breast Surgery, Cancer Hospital/Institute, Fu Dan University, Shanghai 200032 |
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| Abstract: | Objective.To identify a subset of breast cancer patients in whom metastatic disease is confined on-ly to the sentinel lymph node(SLN).Methods.Sentinel lymph node biopsy is performed with the injecetion of Tc99m-SC,and a gamma probe.Sentinel node biopsy was compared with standard axillary dissection for its ability to reflect the fi-nal pathological status of the axillary nodes.The factors associated with non-SLN metastases were as-sessed in the univariate and multivariate analysis.Result.We successfully identified91out of95patients for SLN(95.8%).The accuracy of sentinel lymph node to predict the axillary lymph node status was93.4%.Clinical tumor size and tumor grade were proved to be the independent predictive factors for non-SLN metastases by logistic regression model.Conclusion.In most cases,the gamma probe guided method is technically feasible for detecting sentinel nodes,accurately predicting the axillary lymph node status.A subset of the patients identified who have a low risk of non-SLN metastases may not require axillary lymph node dissection. |
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| Keywords: | breast cancer sentinel lymph node biopsy non-sentinel lymph node |
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