| 全反式维甲酸对人胃癌细胞株增殖的影响 |
| |
| 引用本文： | 许建明 江绍基. 全反式维甲酸对人胃癌细胞株增殖的影响[J]. 中国药理学通报, 1995, 11(5): 377-380 |
| |
| 作者姓名： | 许建明 江绍基 |
| |
| 作者单位： | 安徽医科大学第一附属医院消化内科，上海第二医科大学上海市消化疾病研究所，安徽省立医院 |
| |
| 摘 要： | 研究全反式维甲酸对三株分化程度不同的人胃癌细胞增殖的影响，发现该药对人胃癌细胞株（ＭＫＮ－２８，ＳＧＣ－７９０１）的体外增殖和裸鼠体内移植瘤的生长都有选择性抑制作用，并有不影响细胞活力的特点。而对低分化癌细胞株则无明显作用。进一步研究发现全反式维甲酸可使敏感的胃癌细胞株的３Ｈ－ＴｄＲ掺入值降低，胃癌细胞大多积滞于Ｇ１／Ｇ０期，而Ｇ２／Ｍ期细胞比例相应下降，提示该药对胃癌细胞的ＤＮＡ合成和增殖周期有影响。
|
| 关 键 词： | 全反式维甲酸；人胃癌细胞株；增殖；移植瘤；胸腺嘧啶参入；细胞周期 |
The effect of all trans retinoic acid on the proliferation of human gastric cancer cell lines |
| |
| XU Jian-Ming, SHEN Min, XIAO Shu-Dong et al. The effect of all trans retinoic acid on the proliferation of human gastric cancer cell lines[J]. Chinese Pharmacological Bulletin, 1995, 11(5): 377-380 |
| |
| Authors: | XU Jian-Ming SHEN Min XIAO Shu-Dong et al |
| |
| Abstract: | The effect of all trans retinoic acid on the proliferation of three human gastric cancer cell lines had been studied.The results showed that the drug had a selective inhibitory effect on human gastric cancer cell lines both in vitro and in vivo without evident cytotoxic effect. In the human gastric cancer cell lines whose proliferation were inhibited, 3H-TdR incorporations were decreased and the cells largely accumulated in G1/G0 phase of the cycle while the ratio of the cells in G2/M phase was decreased. |
| |
| Keywords: | all trans retinoic acid human gastric cancer cell line cell proliferation transplanted tumor cell cycle ~3HTdR incorporation |
| 本文献已被 CNKI 维普 等数据库收录！ |
