| 牛磺酸对翻转小鼠离体小肠葡萄糖──钠转运电位的影响 |
| |
| 引用本文： | 崔志清,叶斌.牛磺酸对翻转小鼠离体小肠葡萄糖──钠转运电位的影响[J].中国药理学通报,1995,11(4):288-290. |
| |
| 作者姓名： | 崔志清 叶斌 |
| |
| 作者单位： | 天津医科大学药理教研室，天津职工医学院药理教研室 |
| |
| 摘 要： | 利用翻转小鼠离体小肠囊的方法，观察牛磺酸对葡萄糖－钠转运电位（简称ＰＤ）的影响，借以了解牛磺酸对与糖－钠转运电位密切相关的Ｎａ＋·Ｋ＋－ＡＴＰ酶的影响。结果２．５ｍｍｏｌ·Ｌ－１和５ｍｍｏｌ·Ｌ－１的牛磺酸均可提高ＰＤ（Ｐ＜０．０１），而１０ｍｍｏｌ·Ｌ－１和２５ｍｍｏｌ·Ｌ－１的牛磺酸则对ＰＤ产生相反的作用（Ｐ＜０．０１），推测不同浓度范围的牛磺酸可对Ｎａ＋·Ｋ＋－ＡＴＰ酶产生双向调节作用。
|
| 关 键 词： | 牛磺酸，葡萄糖，钠，跨肠壁电位差 |
The effect of taurine on transmural potential of mouse small intestinein v itro |
| |
| CUI Zhi-Qing, YIE Bin, GUO Shi-Duo, ZHANG Hut-Ru.The effect of taurine on transmural potential of mouse small intestinein v itro[J].Chinese Pharmacological Bulletin,1995,11(4):288-290. |
| |
| Authors: | CUI Zhi-Qing YIE Bin GUO Shi-Duo ZHANG Hut-Ru |
| |
| Abstract: | The electrical potential difference(PD) was measured across the,wall of reverted small intestinal sacs.The effect of taurine on transmural potential related to Na+ andglucosetransport was investlgated.Showing taurlne(2.5 mmol· L-1 and 5 mmol·L-1) increased the PD( P<0.01) .While its dose was increased to 10～25 mmol· L-1,its opposite effect on PD was observed( P<0.01) .Base on the theory of active trasPort of glucose,we inferred that taurine posslblly produces the two way effeet on Na+· K+-ATPase,which may explain whythe different dose of taurine produces distincteffect on zinc transport in smallintestine. |
| |
| Keywords: | taurine glucose transmural potential difference Zinc transport |
| 本文献已被 CNKI 维普 等数据库收录！ |
