A population-based case-control study of Selective Serotonin Reuptake Inhibitors (SSRIs) and breast cancer: The impact of duration of use, cumulative dose and latency |
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| Authors: | JE Ashbury LE Lévesque PA Beck KJ Aronson |
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| Affiliation: | (1) Division of Cancer Care and Epidemiology, Cancer Research Institute, Queen's University, 10 Stuart Street, 2nd Level, Kingston, ON, K7L 3N6, Canada;(2) Department of Community Health and Epidemiology, Carruthers Hall, Queen's University, Kingston, ON, K7L 3N6, Canada;(3) Kingston, Frontenac, Lennox and Addington (KFL&A) Public Health, 221 Portsmouth Avenue, Kingston, ON, K7 M 1V5, Canada;(4) Population Health Branch, Saskatchewan Ministry of Health, T.C. Douglas Building, 3475 Albert Street, Regina, SK, S4 S 6X6, Canada |
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| Abstract: | Background Selective serotonin reuptake inhibitors (SSRIs), a popular class of antidepressants, may increase breast cancer risk by stimulating the secretion of prolactin, a potential tumour promoter. We evaluated the effects of duration of SSRI use, cumulative dose, and latency on the risk of breast cancer by conducting a population-based case-control study utilizing Saskatchewan health databases. |
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