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| 大豆苷元-羟丙基-β-环糊精包合物的研究 | |
| 引用本文： | 葛月宾,,陈大为,谢莉萍,王洪钟,郑桂兰,张荣庆.大豆苷元-羟丙基-β-环糊精包合物的研究[J].中国中药杂志,2006,31(24):2039-2041. |
| 作者姓名： | 葛月宾 陈大为 谢莉萍 王洪钟 郑桂兰 张荣庆 |
| 作者单位： | 1. 清华大学,生物科学与技术系,海洋中心,北京,100084;沈阳药科大学,药学院,药剂学系,辽宁,沈阳,110016 2. 沈阳药科大学,药学院,药剂学系,辽宁,沈阳,110016 3. 清华大学,生物科学与技术系,海洋中心,北京,100084 |
| 摘 要： | 目的：制备难溶性药物大豆苷元的羟丙基-β-环糊精包合物,提高其水溶性。方法：采用溶液搅拌法制备包合物,并对包合物进行差示热分析和热重分析、红外光谱、粉末X-射线衍射分析鉴定,最后测定了包合物的稳定常数。结果：在选定条件下制备的包合物中药物含量为6.76%,溶解度为13.68 mg·mL-1,3种鉴定方法的结果证实形成了包合物。结论：大豆苷元-羟丙基-β-环糊精包合物的制备方法简单可行,达到了增加药物溶解度的目的。 |
| 关 键 词： | 大豆苷元 羟丙基-β-环糊精包合物 溶液搅拌法 |
| 文章编号： | 1001-5302（2006）24-2039-03 |
| 收稿时间： | 4/2/2006 12:00:00 AM |
| 修稿时间： | 2006-04-02 |
Preparation of inclusion complex of daidzein and hydropropyl-β-cyclodextrin |
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| GE Yue-bin;CHEN Da-wei;XIE Li-ping;WANG Hong-zhong;ZHENG Gui-lan;ZHANG Rong-qing.Preparation of inclusion complex of daidzein and hydropropyl-β-cyclodextrin[J].China Journal of Chinese Materia Medica,2006,31(24):2039-2041. | |
| Authors: | GE Yue-bin;CHEN Da-wei;XIE Li-ping;WANG Hong-zhong;ZHENG Gui-lan;ZHANG Rong-qing |
| Institution: | Center of Ocean, Department of Biology Sciences and Biotechnology, Tsinghua University, Beijing 100084, China. |
| Abstract: | OBJECTIVE: To prepare an inclusion complex of daidzein and hydropropyl-beta-cyclodextrin to enhance the solubility of daidzein. METHOD: The inclusion complex of daidzein was prepared by the solution stirring method. The binary system of daidzein and HP-beta-CD was confirmed by differential thermal, thermogravimetry analysis, infrared spectroscopy and X-ray diffractometry. RESULT: The drug content in the inclusion complex was 6. 76% and the solubility was 13.68 mg x mL(-1). The identification results showed that the inclusion complex was formed. CONCLUSION: The preparation method of the inclusion complex of daidzein and hydropropyl-beta-cyclodextrin is simple and available, with a increased solubility of daidzein. |
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