疑似非淋菌性尿道炎患者1572例支原体检测及耐药性分析

目的了解天津大港油田总医院泌尿科、性病科及妇科门诊患者支原体感染及耐药情况。方法应用法国生物-梅里埃公司提供的支原体IST试剂盒进行支原体的培养及药物敏感试验。结果1 572例疑似非淋菌性尿道炎患者中,712例支原体阳性,阳性率为45.3%;解脲支原体(Uu)感染555例(77.9%)、人型支原体(Mh)感染50例(7.0%)及Uu+Mh混合型感染107例(15.0%);其中男性160例(35.1%),女性552例(49.5%),男女感染率比较差别有统计学意义(P<0.05),其中男性Uu+Mh单项感染及Uu、Mh混合型感染分别为125例、11例和24例;女性Uu+Mh单项感染及Uu+Mh混合型感染分别为430例、39例和83例,男女3种类型的感染构成比差别无统计学意义(P>0.05)。药敏结果显示普那霉素、交沙霉素和多西环素对2种支原体均保持高度敏感。结论普那霉素、交沙霉素和多西环素应作为治疗Uu和Mh首选药物,临床治疗前应尽可能进行支原体培养及药敏试验,以合理和规范用药。

Mycoplasma detection and drug tolerance analysis of suspect of nongonococcal urethritis in 1572 eases

Objective To comprehend the status about infection and drug resistance of ureaplasma urealyticum（Uu） and mycoplasma hominis （Mh） in the hospital of Dagang oilfield. Methods Detection and drug sensitivity test of mycoplasma were taken with IST kit of mycoplasma which was produced by biomerieux company in Paris. Results In 1 572 cases with suspect of nongonococcal urethritis,the positive rate of mycoplasma was 45.3 % （712 cases ）. Among these cases, Uu infection rate was 77.9% （555 cases）, Mh infection rate was 7.0% （50 cases）, and the infection rate of Uu and Mh was 15.0% （ 107 cases） ;The male cases were 160（35.1% ） ,the female cases were 552（49.5% ）. There was statistical significance between male and female in infection rate（P 〈 0.05 ）. Among male infection cases, the infection cases of Uu, Mh and Uu ＋ Mh were 125,11 and 24 respectively. Among female infection cases, the infection cases of Uu, Mh and Uu ＋ Mh were 430,39 and 83 respectively. There was no significant difference between male and female in the three infected types（ P 〉 0.05 ）. Drug sensitivity results showed that the two types of mycoplasma have high sensitivity to pristinamycin,josamycin and doxycycline. Conclusion Pristinamycin,josamycin and doxycycline can be used as the choice drug to treat Uu and Mh infection. Cultivation and drug sensitive test of mycoplasma should be done as far as possible,in order to guide the medication reasonably and standardly.