溃疡性结肠炎患者骨密度变化及其相关因素的研究

目的探讨溃疡性结肠炎（UC）患者骨密度（BMD）变化及其与血清中钙、磷、镁、碱性磷酸酶（ALP）、白蛋白（ALB）、肿瘤坏死因子-α（TNF-α）、血管内皮生长因子（VEGF）、白细胞介素-6（IL-6）的相关性。方法用定量CT（QCT）对入选的96例UC患者和100名健康人（对照组）进行BMD测定和相关实验室指标的检测。结果UC组50岁以上者BMD明显低于相应年龄对照组（P〈0.05）;重度UC患者血钙、磷、镁较对照组明显下降（P〈0.05）;BMD与VEGF（r=-0.425,P〈0.05）、TNF-α（r=-0.642,P〈0.05）、IL-6（r=-0.465,P〈0.05）呈负相关。结论UC患者可引起BMD降低而发生骨质疏松,与血钙、磷、镁、白蛋白等营养物质代谢紊乱、年龄、炎性细胞因子等密切有关。

Analysis of risk factors for low bone mineral density in patients with ulcerative colitis

Objective IBD is a gastrointestinal system disorder with a variety of causes. The prevalence of reduced bone mineral density （BMD） is greater in people with IBD as compared with healthy individuals. This paper aimed to investigate the possible risk factors for low BMD in subjects with ulcerative colitis （UC）. Methods A total of 96 subjects with UC and 100 health subjects were enrolled in the study. Serum levels of calcium, phosphate, magnesium, alkaline phosphatase （ALP）, albumin （ALB）, tumor necrosis factor-α（TNF-α）, vascular endothelial growth factor （VEGF）, interleukin-6 （IL-6） were recorded. The BMD was measured by quantitative CT （QCT）. Results The BMD of subjects with UC was found to be lower than that of subjects in the control group. The variation of BMD were associated with VEGF （r=-0.425,P〈0.05）, TNF-α（r=-0.642, P〈0.05）, IL-6 （r = - 0.465, P〈0.05）. Conclusion The BMD of subjects with UC is found to be lower than that of subjects of similar age in the control group. The findings suggest that malnutrition, age and inflammatory cytokines may be the pathogenic factor contributing to low BMD.