阿托伐他汀治疗阵发性心房颤动的疗效观察及与炎性因子的关系

目的 探讨阿托伐他汀治疗阵发性心房颤动的疗效和与炎性因子的关系.方法 将83例发作频繁的阵发性心房颤动(AF)患者,随机分成治疗组(阿托伐他汀联合胺碘酮)和对照组(单用胺碘酮),随访时间半年.结果 治疗组总有效率为81.4%(35/43),对照组总有效率为57.5%(23/40),两组比较差异有统计学意义(P<0.05).两组治疗后C-反应蛋白(CRP)水平、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)的水平均显著下降,且治疗组显著低于对照组,两组比较差异有统计学意义(P<0.05),两组的安全性相当.结论 阿托伐他汀能显著减少阵发性房颤的复发和降低炎性因子水平,且未增加严重不良反应. Abstract： Objective To evaluate the effect and relation to inflammatory factor of atorvastatin on paroxysmal atrial fibrillation.Methods Eighty-three patients with frequent paroxysmal atrial fibrillation were randomly divided into two groups:treatment group received atorvastatin tablet and amiodarone tablet,control group only received amiodarone tablet.All patients were followed up 6 months. Results The total effective rate in the treatment group was 81.4% and 57.5% in the control group with a significant difference (P<0.05). The level of C-reactive protein, tumor necrosis factor-α and interleukin-6 got a obviously decrease after the treatment of the two groups (P<0.05 or P<0.01).But still had a statistical significance between the two groups(P<0.05).In the course of the treatment,both groups were free from obvious side effects.Conclusions Atorvastatin can decrease the palindromia and the level of inflammatory in paroxysmal atrial fbrillation and has no side-effect.

Effect of atorvastatin on paroxysmal atrial fibrillation and its relationship with inflammatory factors