法舒地尔对急性冠状动脉综合征患者血管内皮功能的影响

目的 研究法舒地尔对急性冠状动脉综合征(以下简称急性冠脉综合征)患者血管内皮功能的影响.方法 随机选择急性冠脉综合征患者80例,将入选患者按随机单盲法分为法舒地尔治疗组40例,常规治疗组40例,另外随机选择40例正常人做对照组.分别测定两组治疗前及治疗后4周血浆内皮素、一氧化氮含量.结果 急性冠脉综合征患者血浆一氧化氮水平明显下降,与对照组比较差异有统计学意义(P<0.01);血浆内皮素水平明显升高,与对照组比较差异有统计学意义(P<0.01);急性冠脉综合征组和常规治疗组两组治疗前血浆内皮素、一氧化氮水平比较差异无统计学意义(P>0.05).急性冠脉综合征组治疗后一氧化氮水平较前明显升高, 血浆内皮素水平较前明显降低,与治疗前比较差异有统计学意义(P<0.01),与常规治疗组治疗后比较差异亦有统计学意义(P<0.05).结论 法舒地尔对急性冠脉综合征患者具有保护血管内皮功能的作用.Abstract：Objective To explore the effect of fasudil on vascular endothelial function in patients with acute coronary syndrome.Methods Randomly selected patients with acute coronary syndrome in 80 cases, all patients were selected randomly divided into single-blind fasudil group of 40 patients, 40 patients with conventional treatment group, and randomly selected 40 cases of normal people to the control group. The two groups were measured before and after treatment for 2 weeks ET, nitric oxide.Results Acute coronary syndrome patients with decreased levels of nitric oxide, there was a significant difference compared with the control group (P<0.01).Plasma ET levels were significantly increased compared with the control group,and there was a significant difference (P<0.01).ET, nitric oxide levels were not significantly different between the two groups before treatment (P>0.05). The level of nitric oxide significantly increased, plasma ET levels significantly decreased than that before treatment and the difference was significant (P<0.01), and compared with the conventional treatment group, the difference was also significant (P<0.05).Conclusions Fasudil on patients with acute coronary syndrome has the protection of vascular endothelial function.

Effect of fasudil on endothelial function in patients with acute coronary syndrome

Fasudil Acute coronary syndrome Endothelin Nitric oxide