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Structure and biological activity of cationic [PtLCl(DMSO)]NO(3).DMSO complex containing a chelated diaminosugar: methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside
Authors:Fuks Leon  Samochocka Krystyna  Anulewicz-Ostrowska Romana  Kruszewski Marcin  Priebe Waldemar  Lewandowski Wlodzimierz
Affiliation:Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland. lfuks@ichtj.waw.pl
Abstract:
Cationic platinum(II) complex [Pt(C(7)H(16)N(2)O(2))(DMSO)Cl]NO(3).DMSO containing one chloride anion, methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside (C(7)H(16)N(2)O(2)) and dimethylsulfoxide (DMSO) molecules forming a square-plane has been prepared and characterised, both spectroscopically and by single-crystal X-ray diffraction. Biological tests performed using leukemia L1210 cells have shown that toxicity of the title complex is similar to that of cisplatin.
Keywords:
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