Structure and biological activity of cationic [PtLCl(DMSO)]NO(3).DMSO complex containing a chelated diaminosugar: methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside |
| |
Authors: | Fuks Leon Samochocka Krystyna Anulewicz-Ostrowska Romana Kruszewski Marcin Priebe Waldemar Lewandowski Wlodzimierz |
| |
Affiliation: | Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195, Warsaw, Poland. lfuks@ichtj.waw.pl |
| |
Abstract: | Cationic platinum(II) complex [Pt(C(7)H(16)N(2)O(2))(DMSO)Cl]NO(3).DMSO containing one chloride anion, methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside (C(7)H(16)N(2)O(2)) and dimethylsulfoxide (DMSO) molecules forming a square-plane has been prepared and characterised, both spectroscopically and by single-crystal X-ray diffraction. Biological tests performed using leukemia L1210 cells have shown that toxicity of the title complex is similar to that of cisplatin. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|