| 柏黛膏的体外抗菌活性及其与青霉素的协同抑菌作用 |
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| 引用本文： | 钱丽旗,马建丽,权菊香,郑彬丽,李素那,姚九莲,姜玲敏. 柏黛膏的体外抗菌活性及其与青霉素的协同抑菌作用[J]. 中国临床药理学杂志, 2012, 0(10): 765-766 |
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| 作者姓名： | 钱丽旗 马建丽 权菊香 郑彬丽 李素那 姚九莲 姜玲敏 |
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| 作者单位： | 解放军总医院第一附属医院;北京大学第一医院临床药理研究所;北京神农康源药物研究中心 |
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| 基金项目： | 军队“十一五”科研基金资助项目(No.B086) |
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| 摘 要： | 目的评价柏黛膏抗菌活性及其与青霉素的协同抑菌效能。方法最低抑菌浓度(MIC)测定用琼脂二倍稀释法。结果柏黛膏与青霉素对金黄色葡萄球菌与大肠杆菌具有很好的抗菌活性,柏黛膏+青霉素对金黄色葡萄球菌与大肠杆菌抗菌MIC50和MIC90值分别为0.25,4.00 mg.L-1;1,4 mg.L-1。结论柏黛膏与青霉素对金黄色葡萄球菌、大肠杆菌均有协同抗菌功效。
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| 关 键 词： | 柏黛膏 对葡萄球菌的体外抗菌活性 协同作用 毒霉素 |
Antibacterial activity of medicinal extract for exterior application of BaifDai and its synergy effects with benzylpenicillin in vitro |
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| QIAN Li-qi,MA Jian-li,QUAN Ju-xiang,ZHENG Bin-li, LI Su-na,YAO Jiu-lian,JIANG Ling-min. Antibacterial activity of medicinal extract for exterior application of BaifDai and its synergy effects with benzylpenicillin in vitro[J]. The Chinese Journal of Clinical Pharmacology, 2012, 0(10): 765-766 |
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| Authors: | QIAN Li-qi MA Jian-li QUAN Ju-xiang ZHENG Bin-li LI Su-na YAO Jiu-lian JIANG Ling-min |
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| Affiliation: | 1 (1.Fist Hospital Affiliated to PLA General Hospital,Beijing 100048,China;2.Institute of Clinical Pharmacology,Peking University,First Hospital,Beijing 100034,China;3.Beijing ShengNongKongYuan Research Center,Beijing 100071,China) |
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| Abstract: | Objective To evaluate the antibacterial activity of the medicinal extract for exterior application of BaifDai(MEEAB)combination with benzylpenicillin sodium in vitro.Methods The minimum inhibitory concentration(MIC) was determined by use of two-fold dilution method.Results There was good antibacterial activity of MEEAB combination with benzylpenicillin sodium against Staphylococcus aureus and Escherichia coli.The MIC of MEEAB plus benzylpenicillin sodium against Staphylococcus aureus and Escherichia coli were 0.25,4.00 mg·L-1;1,4 mg·L-1,respectively.Conclusion MEEAB plus benzylpenicillin sodium had more synergy inhibitory effect on the Staphylococcus aureus and Escherichia coli. |
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| Keywords: | medicinal extract for exterior application of BaifDai antibacterial activity on the Staphylococcus aureus synergy effect benzylpenicillin |
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