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| RAM-HPLC测定兔眼房水中丝裂霉素C的含量 | |
| 引用本文： | 高国敬, 王登旭, 李艳. RAM-HPLC测定兔眼房水中丝裂霉素C的含量[J]. 中国现代应用药学, 2008, (6): 531-533. |
| 作者姓名： | 高国敬 王登旭 李艳 |
| 作者单位： | 山东省聊城市药品检验所,山东,聊城252000 |
| 摘 要： | 目的测定兔眼房水中缓释丝裂霉素C的含量。方法使用TSP高效液相色谱仪,Anastar工作站;分析柱:RAM(4.6mm×150 mm,5μm);流动相:甲醇-水(10∶90),流速:1.0 mL.min-1,检测波长:365 nm。结果色谱峰分离度良好,丝裂霉素在0.001~0.005 mg.mL-1内线性关系良好,平均回收率为99.1%,102.3%,103.6%,RSD为3.3%,2.9%,1.8%。结论本法准确简单,精密度好,是测定兔眼房水中缓释丝裂霉素C释放过程的适宜方法。 |
| 关 键 词： | 丝裂霉素C 高效液相色谱法 含量测定 缓释 房水 |
Determination of Sustained-release of Mitomycin C by RAM-HPLC and Its Application in Glaucoma Filtering Surgery |
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| GAO Guo-jing, WANG Deng-xu, LI Yan. Determination of Sustained-release of Mitomycin C by RAM-HPLC and Its Application in Glaucoma Filtering Surgery[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (6): 531-533. | |
| Authors: | GAO Guo-jing WANG Deng-xu LI Yan |
| Abstract: | OBJECTIVE To simultaneously determine the concentration of mitomycin C(MMC) in aqeous of rabbit eyes.METHODS A direct injection method for determination of MMC in body fluid and Solution by restricted-access media(RAM)-HPLC was developed.The mobile phase |
| Keywords: | mitomycin C HPLC content determination sustained-release aqueous |
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