| 糖尿病大鼠肾脏抗氧化防御机能的变化 |
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| 引用本文： | 倪连松,吴万龄,盛宏光,杨裕国. 糖尿病大鼠肾脏抗氧化防御机能的变化[J]. 温州医学院学报, 2001, 31(1): 6-8 |
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| 作者姓名： | 倪连松 吴万龄 盛宏光 杨裕国 |
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| 作者单位： | 1. 温州 医学院附属第一医院 内分泌科,
2. 上海第二医科大学附属第九人民医 院 内分泌科, |
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| 摘 要： | 目的：探讨糖尿病对肾脏抗氧化防御机能的影响。方法：观察12周糖尿病大鼠肾皮质丙二醛（MDA）及谷胱甘肽（GSH）水平，以及超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH－PX）、谷胱甘肽S－转移酶（GSH－ST）和过氧化氢酶（CAT）活性的变化。结果：糖尿病大鼠肾组织中SOD、GSH－ST及CAT活性下降，GSH含量显降低；MDA没有变化；GSH－PX活性却明显增强。结论：糖尿病大鼠肾组织抗氧化防御机能明显下降。
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| 关 键 词： | 糖尿病肾病 氧化还原 应激 自由基 大鼠 |
| 文章编号： | 1000-2138(2001)01-0 006-03 |
| 修稿时间： | 1999-12-16 |
Study of the antioxidantdefense system in the kidney of diabetic rats |
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| NI Lian song,WU Wan ling,SHENG Hong guang,et al.. Study of the antioxidantdefense system in the kidney of diabetic rats[J]. Journal of Wenzhou Medical College, 2001, 31(1): 6-8 |
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| Authors: | NI Lian song WU Wan ling SHENG Hong guang et al. |
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| Affiliation: | NI Lian song,WU Wan ling,SHENG Hong guang,et al. Department of Endocrinology,1st Affiliated Hospital,Wenzhou Medical College,Wenzhou,325000 |
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| Abstract: | Objective:To study the effect of diabetes on renal antioxidant defense function.Methods:The levels of malondialdehyde (MDA), glutathione (GSH), and the activities of antioxidant enzymes viz., [superoxide dismutase (SOD), glutathione peroxidase (GSH PX), glutathione s transferase (GSH ST) and catalase (CAT)] were investigated in the renal cortex of diabetic rats at 12th week.Results:The activities of SOD, GSH-ST and CAT were significantly lower in the diabetic group than normal one. The level of GSH was decreased too, MDA showed no change, whereas GSH PX activity of the diabetic group was theincreased.Conclusion:The antioxidant defense function in the kidney of diabetic rats decreased obviously. |
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| Keywords: | diabetic nephropathy oxidative reduction stress free radicals |
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