Survival of Cajal-Retzius cells after cortical lesions in newborn mice: a possible role for Cajal-Retzius cells in brain repair |
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| Affiliation: | 1. From Department of Ophthalmology, Dell Medical School, Austin, TX (E.C.B);2. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA (A.C, S.J.G, W.J.F, E.S);3. University of Toronto, Toronto, Canada (P.G.C, I.I.K.A);4. Department of Ophthalmology, University of California San Francisco, San Francisco, CA (Y.H);5. Department of Ophthalmology, University of North Carolina, Chapel Hill, NC, USA (D.L.B);1. Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA;2. Department of Mechanical Engineering, University of South Carolina, Columbia, SC 29208, USA;1. Tianjin Key Lab of Advanced Joining Technology, School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China;2. Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of Education, School of Materials Science and Engineering, Tianjin University, Tianjin 300350, China;1. School of Economics and Center of Social Welfare and Governance, Zhejiang University, China;2. School of Public Affairs, Zhejiang University, China;3. School of Economics, Zhejiang University, China;4. School of Economics and Jinan University - University of Birmingham Joint Institute, Jinan University, China |
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| Abstract: | ![]()
Transient Cajal-Retzius (CR) cells in layer I of the mammalian cerebral cortex are the first postmitotic neurons and they are believed to play a role in neuronal migration and lamination during cortical development. Freezing insults to the cortex of newborn mice produce cortical malformations similar to those observed in human brain disorders. Here we have used calretinin immunostaining to investigate the response of CR cells to freezing lesions of the cortical surface. Shortly after injury, CR cells disappeared from the lesioned zone. Moreover, CR cells located near the lesioned area adopted extremely fusiform shapes. At later postnatal stages (P12), CR cells were still abundant in layer I of the lesioned zone, in contrast to their almost complete loss in control animals. These results show that CR cells survive for longer developmental periods following cortical injury. Furthermore, the initial loss and later re-appearance of CR cells suggest that these neurons might migrate tangentially from the cortical areas surrounding the lesioned zone. These findings imply a role for CR cells in brain repair after cortical injury during development. |
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