口腔鳞癌中粘着斑激酶的表达及意义

目的探讨粘着斑激酶（FAK）在人口腔鳞状细胞癌（OSCC）中的表达水平及与各临床病理因素和预后的关系。方法免疫组化SP法检测80例人OSCC石蜡切片中的FAK的表达情况。采用X^2检验、生存曲线和Cox比例风险回归等方法分析FAK过表达的意义。结果免疫组化证实FAK为非均质性表达，主要强表达在癌细胞质和（或）细胞膜中．在对应癌旁正常组织中则呈弱阳性或阴性表达。采用前沿区染色计分的结果判断方法，FAK过表达与癌的分期、分化、淋巴结转移相关性显著；多因素分析显示，FAK过表达可作为判断口腔鳞癌预后的危险因紊，为影响预后的独立因素。结论口腔鳞癌前沿区的FAK过表达为有价值的判断其生物学行为和预后的病理学指标。

Expression and Clinical Significance of Focal Adhesion Kinase in Oral Squamous Cell Carcinoma

Objective To study the correlation between expression levels of focal adhesion kinase (FAK) in oral squamous cell carcinoma (OSCC) and clinical prognosis with pathologic parameters. Methods Eighty paraffin embedded tissue specimens of OSCC were studied by immunohistochemistry. The data was analyzed by SPSS statistical software. Results FAK was highly expressed in OSCC tissues, in contrast to none or a low expression in normal oral epithelial tissue,and the heterogeneous staining was mainly located in the cell membrane and cytoplasm. FAK overexpression significantly correlated with histological differentiation and TNM stage, lymphatic metastasis. Multivariate analysis revealed that overexpression of FAK was the independent prognostic factor. Conclusion The overexpression of FAK in the peripheral area of OSCC may serve as a useful biological factor affecting prognosis.