溶血磷脂酸和人附睾蛋白4联合检测在卵巢癌诊断中的价值

目的溶血磷脂酸(LPA)和人附睾蛋白4(HE4)联合检测在卵巢癌诊断中的价值。方法 50例卵巢癌患者作为A组,45例卵巢良性病变患者作为B组,100例健康查体者作为C组。测定3组血清LPA和HE4。结果 A组HE4和LPA均高于B组和C组(P<0.01),但血清HE4和LPA在B、C两组之间无明显差异(P>0.05)。LPA诊断卵巢癌敏感度为70.0%,特异度为95.2%,准确度为88.7%;HE4诊断卵巢癌的敏感度为80.0%,特异度为97.2%,准确度为92.8%。联合检测时,诊断卵巢癌的敏感度为94.0%,而特异度为93.1%,准确度为93.3%,高于单项检测的敏感度与准确度(P<0.05)。结论联合测定血清LPA和HE4可以较敏感和准确的诊断卵巢癌。

Combined Detection of Lysophosphatidic Acid and Human Epididymis Protein 4 on Diagnosis for Ovarian Cancer

Objective To study combined detection of lysophosphatidic acid （LPA）and human epididymis protein 4（HE4） on diagnosis for ovarian cancer. Methods 50 patients with ovarian cancer were enrolled into A group,45 patients with benign ovarian were enrolled into B group and 100 healthy people were enrolled into C group. Serum LPA and HE4 were detected. Results A group of HE4 and LPA were higher than in group B and group C（P〈0.01）, but the serum HE4 and LPA in B, C no significant difference between the two groups（P〉0.05）. LPA diagnosis of ovarian cancer, sensitivity was 70.0%, specificity 95.2% and accuracy was 88.7%; HE4 ovarian cancer diagnostic sensitivity of 80.0% and a specificity of 97.2% and accuracy was 92.8%. Joint detection, diagnosis of ovarian cancer with a sensitivity of 94.0%, while specificity was 93.1% and accuracy was 93.3%, higher than the single detection sensitivity and accuracy （P〈0.05）.Conclusions Joint serum LPA and HE4 can be more sensitive and accurate diagnosis of ovarian cancer.