2型糖尿病合并肾病患者血清内皮素含量的临床分析

目的探讨2型糖尿病合并肾病患者尿微量白蛋白（UM）和内皮素（ET）的变化及其临床意义。方法选择2型糖尿病合并肾病患者30例（A组），并与2型糖尿病无血管并发症者（B组）、糖耐量受损（IGT）者（C组）作比较；同时选择有2型糖尿病家族史健康人（D组）和无2型糖尿病家族史健康人（E组）各30例作为对照，分别检测UM、ET并进行统计分析。结果A组与其他4组比较，UM含量有显著差异（P〈0．05），而B、C、D、E组间UM含量无显著性差异（P〉0．05）；A组ET含量明显高于其他4组（P〈0.01），E组明显低于其他4组（P〈0.01）。结论2型糖尿病患者存在内皮功能损伤，且随着病程的进展而发展，合并肾病并发症与内皮功能损伤，两者变化同步，提示血管内皮损伤与肾病并发症有关，同糖尿病病程进展相关。

Clinical analysis of serum endothelin in type 2 diabetic patients with vascular complications

OBJECTIVE: To explore the clinical significance of changes in urine microalbumin (UM) and endothelin (ET) in different courses of type 2 diabetes. METHODS: A clinical analyses of 30 type 2 diabetic patients with vascular complications (group A) was conducted in comparison with type 2 diabetic patients without vascular complications (group B) and patients with impaired glucose tolerance (IGT, group C). With 30 healthy subjects with family history of type 2 diabetes (group D) and 30 healthy subjects without such family history (group E) as controls, UM and ET were determined in all the subjects for a statistical analysis. RESULTS: Significant differences in UM content was noted between group A and the other 4 groups (P<0.05), while the content did not differ significantly between the latter 4 groups (P>0.05). ET content was significantly higher in group A than in the other 4 groups (P<0.01), and was the lowest in group E (P<0.01). CONCLUSIONS: Type 2 diabetic patients sustain extensively impaired endothelium function, which is exacerbated with the progression of the disease courses. Synchronized changes between vascular complications and impaired endothelium function indicates that vascular endothelial injury relates to vascular complications and the progression of diabetes.