Nitric oxide in paraventricular nuclei of rat hypothalamus under extreme conditions |
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| Authors: | O. V. Fidelina O. S. Gorbatyuk I. G. Akmaev |
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| Affiliation: | (1) Institute of Experimental Endocrinology, Endocrinology Research Center, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | The activity of nitroxide synthetase (NOS) was studied histochemically and levels of oxytocin and vasopressin immunocytochemically
in rat hypothalamus paraventricular nuclei in on-earth experiments simulating space flight conditions with landing. Colonization
of oxytocin and NOS was found in large-cell neurons of paraventricular nuclei. After 15 days under conditions of simulated
microgravitation followed by 1-day double gravitation and a short-term (1 day) macrogravitation, activities of NOS and content
of neuropeptides increased in large-cell neurons of paraventricular nuclei of experimental animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 282–284, March, 1998 |
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| Keywords: | hypothalamic paraventricular nuclei
NADPH-diaphorase
nitroxide synthetase
oxytocin
vasopressin
micro- and macrogravitation |
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